Tony Giordano's Publications

Giordano, T. and Howard, B. (1989) Utilization of Magnetic Affinity Cell Sorting (MACS) for the Isolation of Stable Transfectants. Nucleic Acids Research 17, 7540.

Giordano, T., Kleinsek, D. and Foster, D.N. (1989) Increase in Abundance of a Transcript Hybridizing to Elongation Factor I Alpha during Cellular Senescence and Quiescence. Experimental Gerontology 24, 501-513.

Giordano, T. and Foster, D.N. (1989) Identification of a Highly Abundant cDNA from Late Passage WI-38 Cells. Experimental Cell Research 185, 399-406.

Giordano, T., Sakamoto, K., and Howard, B.H. (1990) Detection of protein/RNA interactions in nuclear extracts is facilitated by poly r(G). Nucleic Acids Research 18, 4627.

Giordano, T., Howard, T.H., Coleman, J., Sakamoto, K., and Howard, B.H. (1991) Isolation of a Population of Transiently Transfected Quiescent and Senescent Cells by Magnetic Affinity Cell Sorting. Experimental Cell Research 192, 193-197.

Giordano, T., Pan, J.B., Casuto, D., Watanabe, S., and Arneric , S.A. (1992) Thyroid Hormone Regulation of NGF, NT-3 and BDNF RNA in the Adult Rat Brain. Molecular Brain Research 16, 239-245.

Chandrasekaran, K., Stoll, J., Giordano, T., Atack, J.R., Matocha, M.F., Brady, D.R., Rapoport, S.I. (1992) Differential Expression of Cytochrome Oxidase (COX) Genes in Different Regions of Monkey Brain. J. Neuroscience Research 32, 415-423 .

Giordano, T., Johnson , S.A. , Sakamoto, K., and Howard, B.H. (1992) Expression of Alu and 7SL RNA in Alzheimer's and Control Brains. Mechanisms of Ageing and Development 64,13-20.

Foster, D.N., Gailhouse, D., Giordano, T., Min, B.-H., Lamb, I.C., Porter, D.A., Intehar, K.J. and Bacon, W.L. (1992) Nucleotide Sequence of the cDNA Encoding the Common alpha Subunit of Chicken Pituitary Glycoprotein Hormones. J. Molecular Endocrinology 8, 21-27.

Williams, M., Giordano, T., Reiser, H.J., and Neil, G.L. (1993) Biotechnology in the Drug Discovery Process: Strategic and Management Issues. Med. Res. Reviews 13, 399-448.

Pan, J.B., Monteggia, L.M., and Giordano, T. (1993) Altered Levels and Splicing of the Amyloid Precurser Protein in the Adult Rat Hippocampus after Treatment with DMSO or Retinoic Acid. Molecular Brain Research 18, 259-266.

Wadhwani, K.C., Fukuyama , R., Giordano, T., Rapoport, S.I., and Chandrasekaran, K. (1993) Quantitative Reverse Transcriptase-Polymerase Chain Reaction of Glucose Transporter 1 mRNA Levels in Rat Brain Microvessels. Analytical Biochemistry 215, 134-141.

Doucette-Stamm, L., Monteggia, L.M., Donnelly-Roberts, D., Wang, M.T., Lee, J., Tian, J., and Giordano, T. (1993) Cloning and Sequence of the Human a7 Nicotinic Acetycholine Receptor. Drug Development Research 30, 252-256.

Giordano, T., Pan, J.B., Monteggia, L.M., Holzman, T.F., Krafft, G., Ghanbari, H. and Kowall, N.W. (1994) Similarities Between ß Amyloid Peptides 1-40 and 40-1: Effects on Aggregation, toxicity in vitro , and Injection in Young and Aged Rats. Experimental Neurology 125, 175-182.

Monteggia, L.M., Arneric, S.P., and Giordano, T. (1994) Nicotine Effects on the Regulation of APP Splicing, Neurotrophin and Glucose Transporter RNA Levels in Aged Rats. J. International Developemental Neuroscience 12, 133-142.

Chandrasekaran, K., Giordano, T., Brady, D., Stoll, J., Martin, L.J. and Rapoport, S.I. (1994) Alzheimer Disease: Impairments in Mitochodrial Cyctochrome Oxidase mRNA Gene Expression in Temporal Neocortex. Molecular Brain Research 24:336-340.

Briggs , C.A. , Hughes, M.L., Monteggia, L.M., Giordano, T., Donnelly-Roberts, D., and Arneric, S.P. (1995) Ganglionic Nicotinic Acetylcholine Receptor Activation by the Novel Agonist ABT-418. Drug Devel. Res. 34:39-46.

Monteggia, L.M., Gopalakrishnan, M., Touma, E., Idler, K., Nash, N., Arneric, S.P., Sullivan, J.P., and Giordano, T. (1995) The Cloning and Transient Expression of the Human a4 and ß2 Neuronal Nicotinic Acetycholine Receptor (nAChR) Subunits. Gene 155:189-193.

Gopalakrishnan, M., Buisson, B., Touma, E., Giordano, T., Campbell , J.E., Hu, I.C., Bertrand, D., Donnelly-Roberts, D., Arneric, S.P., and Sullivan, J.P. (1995) Pharmacological Characterization of the Human a7 Neuronal Nicotinic Acetylcholine Recptor Subtype Stably Expressed in a Mammalian Cell Line. European J. of Pharmacology 290:237-246.

Jacobs, D.B., Mandelin, A.M., Giordano, T., Xue-Hu, I. , Malter, J.S., Snyder, A.K., and Singh, S.P. (1996) Demonstration of an AUUUA-Specific mRNA Binding Protein in Astrocytes. Life Sciences. 58:2083-2089.

Carver, J.M., Mansson, P.-E., Cortes-Burgos, L., Shu, J., Zhou, L.-M., Howe, J.R., and Giordano, T. (1996) Cytotoxic Effects of Kainate Ligands on HEK Cell Lines Expressing Recombinant Kainate Receptors. Brain Research 720:69-74.

Zhou, L.-M., Gu, Z.-Q., Costa, A.M., Yamada, K.A., Mansson, P.-E., Giordano, T., Skolnick, P., and Jones, K.A. (1997) (2S,4R)-4-Methylglutamic Acid (SYM2081): A Potent, Selective Probe for Kainate Receptors. J. Pharm. Exp. Ther. 280:422-427.

Lin, Y.J., Carver, J.M., and Giordano, T. (1996) The Cloning and Expression in the CNS and Periphery of the Human NR2C NMDA Glutamate Receptor. Mol. Brain Res. 43:57-64.

Bhattacharya, S., Giordano, T., Brewer, G. and Malter, J.S. (1999) Identification of AUF-1 Ligands Reveals Vast Diversity of Early Response Gene mRNAs. Nucl. Acids Res. 27:1464-1472.

Xavier, K.A., Eder , P.S. and Giordano, T. (2000) RNA as a Drug Target: Methods for Biophysical Characterization and Screening. Trends in Biotechnology 18:349-356.

Malin, D.H., Crothers, M.K., Lake , J.R., Goyarzu, P., Plotner, R.E., Garcia , S.A. , Spell, S.H., Tomsic, B.J., Giordano, T. and Kowall, N.W. (2001) Hippocampal Injections of Amyloid Beta Peptide 1-40 Impair Subsequent One-Trial/Day Reward Learning. Neurobiology of Learning and Memory. 76:125-37.

Pillutla, R., Hsiao, K., Brissette, R., Eder , P., Giordano, T., Fletcher, P., Lennick, M., Blume, A. and Goldstein, N. (2001) A surrogate-based approach for post-genomic partner identification. BMC Biotechnology 1: 6

Rogers, JT, Randall, JD, Eder, PS, Huang, X, Bush, AI, Tanzi, RE, Venti, A, Payton, SM, Giordano, T, Nagano, S, Cahill, CM, Moir, R, Lahiri, DK, Greig, N, Sarang, SS, and Gullans, SR. (2002) Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. J Mol Neurosci. 19:77-82.

Rogers, JT, Randall, JD, Cahill, CM, Eder, PS, Huang, X, Gunshin, H, Leiter, L, McPhee, J, Sarang, SS, Utsuki, T, Greig, NH, Lahiri, DK, Tanzi, RE, Bush, AI, Giordano, T, and Gullans SR. (2002) An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem. 277(47):45518-28.

Shuey, D.J., McCallus, D.E., Giordano, T. (2002) RNAi: gene-silencing in therapeutic intervention. Drug Discovery Today. 7:1040-1046.

Chopra, M., Pachuck, C., Satishchandran, C., Giordano, T. (2002) Using RNA interference to modulate gene expression. Targets 1: 102-108.

Zhu, X., Giordano, T., Yu, Q., Holloway, H.W., Perry, T.A., Lahiri, D.K., Brossi, A., Greig , N.H. (2003) Thiothalidomides: Novel isoteric analogues of thalidomide with enhanced TNF- inhibitory activity. J. Med. Chem. 46:5222-5229.

Greig , N.H. , Giordano, T., Zhu, X., Yu, Q.-S., Perry, T.A., Holloway, H.W., Utsuki, T., Brossi, A., Rogers , J.T., Sambamurti, K., Lahiri, D.K. (2004) Thalidomide-based TNF- inhibitors for neurodegenerative diseases. Acta. Neurobiol. Exp. 64:1-9.