Dr. Eric First's Publications

Austin, J., and First, E. A., Journal of Biological Chemistry 277, . "Comparison of the Catalytic Roles Played by the KMSKS Motif In the Human and Bacillus stearothermophilus Tyrosyl-tRNA Synthetases."

Austin, J., and First, E. A., Journal of Biological Chemistry 277, (2002).  "Potassium functionally replaces the second lysine of the KMSKS signature sequence in human tyrosyl-tRNA synthetase."

Austin, J., and First, E. A., Journal of Biological Chemistry 277, (2002). "Catalysis of Tyrosyl-Adenylate Formation by the Human Tyrosyl-tRNA Synthetase."

Xin, Y., Li, W., and First, E. A., Journal of Molecular Biology 303, 299-310 (2000). "Stabilization of the Transition State for the Transfer of Tyrosine to tRNA^Tyr."

Xin, Y., Li, W., Dwyer, D., and First, E. A., Journal of Molecular Biology 303, 287-298 (2000). "Correlating Amino Acid Conservation with Function in Tyrosyl-tRNA Synthetase."

Xin, Y., Li, W., and First, E. A., Biochemistry 39, 340-347 (2000). "The 'KMSKS' Motif in Tyrosyl-tRNA Synthetase Participates in the Initial Binding of tRNA^Tyr."

Kleeman, T. A., Wei, D., Simpson, K. L., First, E. A., The Journal of Biological Chemistry 272, (1997).  "Human Tyrosyl-tRNA Synthetase Shares Amino Acid Sequence Homology with a Putative Cytokine."

First, E. A. and Fersht, A. R., Biochemistry 34, 5030-5043 (1995). "Analysis of the Role of the KMSKS Loop in the Catalytic Mechanism of the Tyrosyl-tRNA Synthetase Using Multimutant Cycles."

First, E. A. and Fersht, A. R., Biochemistry 32, (1993). "Mutational and Kinetic Analysis of a Mobile Loop in Tyrosyl tRNA Synthetase."

First, E. A. and Fersht, A. R., Biochemistry 32, (1993). "Mutation of Lysine 233 to Alanine Introduces Positive Cooperativity into Tyrosyl-tRNA Synthetase."

First, E. A. and Fersht, A. R., Biochemistry 32, (1993). "Involvement of Threonine 234 in  Catalysis of Tyrosyl Adenylate Formation by Tyrosyl-tRNA Synthetase."

First, E. A., Johnson, D. A., and Taylor, S. S. , Biochemistry 28, 3606-3613 (1989). "Fluorescence Energy Transfer between Cysteine 199 and Cysteine 343: Evidence for MgATP-Dependent Conformational Change in the Catalytic Subunit of cAMP-Dependent Protein Kinase."

First, E. A. and Taylor, S. S., Biochemistry 28, 3598-3605 (1989). "Selective Modification of the Catalytic Subunit of cAMP-Dependent Protein Kinase with Sulfyhdryl-Specific Fluorescent Probes."

First, E. A., Bubis, J., and Taylor, S. S., Journal of Biological Chemistry 263, 5176-5181 (1988). "Subunit Interaction Sites between the Regulatory and Catalytic Subunits of cAMP  Dependent Protein Kinase.  Identification of a Specific Interchain Disulfide Bond."

First, E. A. and Taylor, S. S., Journal of Biological Chemistry 263, 5170-5175 (1988). "Subunit Interaction Sites between the Regulatory and Catalytic Subunits of cAMP- Dependent  Protein Kinase.  Heterobifunctional Cross-linking Reagents Lead to Photodependent and Photoindependent Cross-linking."

Taylor, S. S., Bubis, J., Toner-Webb, J., Saraswat, L. D., First, E. A., Buechler, J. A., Knighton, D. R. and Sowadaski, J. , FASEB Journal 2, 2677-2685 (1988). "cAMP-Dependent Protein Kinase:  Prototype for a Family of Enzymes."

First, E. A. and Taylor, S. S., Journal of Biological Chemistry 259, 4011-4014 (1984). "Induced Interchain Disulfide Bonding in cAMP-Dependent Protein Kinase II."

BOOK CHAPTERS

First, E. A. (1997). "Catalysis of tRNA aminoacylation by class I and class II aminoacyl-t RNA synthetases. In Comprehensive Biological Catalysis.  A Mechanistic Reference., M. Sinnott, ed. (London: Academic Press), pp. 573-607.