Dr. Arrigo De Benedetti's Publications

Li BD, Gruner JS, Abreo F, Johnson LW, Yu H, Nawas S, McDonald JC, DeBenedetti A. (2002) Prospective study of eukaryotic initiation factor 4E protein elevation and breast cancer outcome.  Ann Surg. 235(5):732-738.

DeFatta, RJ, Li, Y., and De Benedetti, A. (2002) Selective killing of cancer cells based on translational control of a suicide gene. Cancer Gene Therapy 9: 573-578.

DeFatta, RJ., Chervenak, RP., and De Benedetti, A. (2002) A novel approach to cancer gene therapy based on translational control of a suicide gene. Cancer Gene Therapy 9: 505-512

Li,  Y., DeFatta, R.J, Sunavala, G., Anthony, C., and De Benedetti, A. (2001). A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed. Oncogene 20: 726-738.

Berkel, HJ., Turbat-Herrera, EA., Shi, R., and De Benedetti, A. (2001)  Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon.  Cancer Epidem. Biomarkers & Prevention 10: 663-666.

Anthony, C., Zong, Q., and De Benedetti, A. (2001) Overexpression of eIF4E in S. cerevisiae causes slow growth and decreased a-factor response through alterations in Cln3 expression.  J. Biol. Chem. 276:

Zimmer, S.G., De Benedetti, A., Graff, J.R. (2000) Translational control of malignancy: the mRNA cap-binding protein, eIF4E, as a central regulator of tumor formation, growth, invasion and metastasis.  Anticancer Res. 20: 1343-1351.

Crew JP, Fuggle S, Bicknell R, Cranston DW, De Benedetti A, Harris AL. (2000) Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression. Br. J. Cancer 82: 161-166.

DeFatta, RJ, Nathan, CO, and De Benedetti A. (2000)  Antisense RNA to eIF4E suppresses oncogenic properties of a HNSCC cell line. The laryngoscope 110: 928-933.

De Benedetti, A. and Harris, A.L. (1999) eIF4E expression in tumors: its possible role in progression of malignancies.  Int.J.Biochem.Mol.Biol. 31: 59-72.

Sorells, DL,Gahli, EG., Meschonat, C., DeFatta, RJ., Black, D.,Li, L., De Benedetti, A., Nathan, CA, and Li, BDL. (1999) Competitive PCR to detect eIF4E gene amplification in Head and Neck cancers. Head & Neck 21: 60-65.

DeFatta, R.J., Turbat-Herrera, E.A., Li, B.D.L., Anderson, W., and De Benedetti, A. (1999) Elevated Expression of eIF4E in Confined Early Breast Cancer Lesions: Possible Role of Hypoxia.  Int. J. Cancer. 80: 518-522.

Carter, P.S. Jarquin, M., and De Benedetti, A.(1999)  Differential expression of Myc1 and Myc2 isoforms in cells transformed by eIF4E: evidence for internal ribosome repositioning in the human c-myc 5'UTR. Oncogene 18: 4326-4335.

Franklin S., Pho T., Abreo F., Nassar R., DeBenedetti A., Stucker F., Nathan C.O. (1999) mmunohistochemical Detection of the Proto-Oncogene eIF4E in Larynx and Hypopharynx Cancers. Archives of Otolaryngology/Head & Neck Surgery 125: 177-182.

Sorrells DL Jr. Ghali GE. De Benedetti A. Nathan CA. Li BD. (1999) Progressive amplification and overexpression of the eukaryotic initiation factor 4E gene in different zones of head and neck cancers. Journal of Oral & Maxillofacial Surgery. 57: 294-299.

Nathan, CO., Franklin, S., Abreo, F., Nassar R., De Fatta, R., De Benedetti A., Stucker, FJ, Glass, J. (1999) Analysis of Surgical Margins with the Molecular Marker  eIF4E: A prognostic factor in patients with Head & Neck cancer. J. Clin. Oncology 17: 1-6.

Franklin, S., Pho, T., Abreo, F., Nassar, R., De Benedetti, A., Stucker, F., and Nathan, CA. (1999)  Detection of the proto-oncogene eIF4E in larynx and hypopharynx cancers.  Arch. Otolaryng. Head Neck Surg. 125: 117-182.

Nathan, CO., Franklin, S., Abreo, F., Nassar R., De Benedetti A., Williams, J. Stucker, F.  (1999) Expression of eIF4E during Head and Neck tumorigenesis: Possible role in angiogenesis.  The laryngoscope 109: 1253-1258.

Abid, R., Li, Y., and De Benedetti, A. (1999) Translational regulation of ribonucleotide reductase by eIF4E links protein synthesis to the control of DNA replication. J. Biol. Chem. 274: 35991-35998.

Li, BDL, McDonald, J., Nassar, R., and De Benedetti A. (1998) Clinical outcome in stage 1 to 3 breast carcinomas and eIF4E overexpression. Annals of Surg.Soc. 227: 756-763.

Scott, P.A.E.,  Smith, K., Poulsom, R., De Benedetti, A., Bicknell, R., and Harris, A.L. (1998)  Differential expression of vascular endothelial growth factor mRNA versus protein isoforms expression in human breast cancer and relationship to eIF4E.  Brit. J. Cancer 77: 2120-2128.

Sorells, DL, Black, D., Meschonat, C., Rhoads, R., De Benedetti, A., Gao, M., Williams B.J., and Li, BDL. (1998) Detection of eIF4E gene amplification in breast cancer by competitive PCR.  Annals of Surg. Onc. 5: 232-237.

Li, BDL, Liu, L., Dawson, M., and De Benedetti, A. (1997).  Overexpression of eukaryotic initiation factor 4E (eIF4E) in Breast Carcinoma. Cancer 79: 2385-2389.

Graff, J.R., De Benedetti, A., Olson, J.W., Tamez, P., Casero, RA, and Zimmer, S.G. (1997) Translation of ODC mRNA and polyamine transport are suppressed in ras-transformed CREF cells by depleting translation initiation factor 4E.  BBRC 240: 15-20.

Nathan C.A., Liu, L., Li, BDL, Abreo, F., Nandy, I., and De Benedetti, A (1997).  Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer.  Oncogene 15: 579-584.

Nathan, C.A., Carter, P., Liu, L., Li, BDL., Abreo, F., Tudor, A., Zimmer, S. and De Benedetti, A. (1997). Elevated Expression of eIF-4E and FGF-2 isoforms During Vascularization of Breast Carcinomas. Oncogene 15: 1087-1095.

Kevil, C., De Benedetti, A., Payne, K.D., Coe, L.L., Laroux, S., and Alexander, S. (1996).  Translational regulation of Vascular Permeability Factor by eukaryotic initiation factor 4E: Implications for tumor angiogenesis. Int. J. Cancer 65: 785-790.

Anthony, B., Carter, P., and De Benedetti, A. (1996).  Overexpression of the protooncogene/translation factor eIF-4E in breast carcinoma cell lines. Int. J. Cancer 65: 858-863.

Kevil C., Carter, P., Hu, B., and De Benedetti, A. (1995). Translational enhancement of  FGF-2 by eIF-4 factors, and alternate utilization of CUG and AUG codons for translation initiation.  Oncogene 11: 2339-2348.

Bommer, U.A., Lazaris-Karatzas, A., De Benedetti, A., Nurenberg, P., Benndorf, R., Bielka, H., & Sonenberg, N. (1995).  Translational regulation of the mammalian growth-related protein P23: Involvement of eIF-4E phosphorylation. Cell. Mol. Biol. Res. 40: 633-641.

Kerekatte, V., Smiley, K., Hu, B., Smith, A., Gelder, F., and De Benedetti, A.(1995). The Protooncogene/Translation Factor eIF-4E - A Survey of its Expression in Breast Carcinomas.  Int. J. Cancer  64: 27-31.

Graff, J.R., Boghaert, E.R., De Benedetti, A., Tudor, D.M., and Zimmer, S.G. (1995).  Reduction of translation initiation factor 4E reduces tumor growth, invasion and metastasis of ras-transformed cloned rat embryo fibroblast. Int. J. Cancer  60: 255-263.

De Benedetti, A., Joshi, B., Graff, J.R., Zimmer, S.G. (1994).  CHO cells transformed by the translation factor eIF-4E display increased c-myc expression, but require overexpression of Max for tumorigenicity. Mol. Cell. Diff. 2: 347-371.

Barve, S.S., Cohen, D.A., De Benedetti, A., Rhoads, R.E., and Kaplan, A.M. (1994).  Induction of IL-2 transcription in Th2 cells by upregulation of transcription factors with the protein synthesis initiation factor 4E.  J. Immunology 152:1171-1181.

Rinker-Schaeffer, C.W., Graff, J.R., De Benedetti, A., Zimmer, S.G., and Rhoads, R.E. (1993).  Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned Rat Embryo Fibroblasts.  Int. J. Cancer  55:841-847.

Joshi-Barve, S., De Benedetti, A., and Rhoads, R.E. (1992). Preferential translation of heat shock mRNAs in HeLa cells deficient in protein synthesis initiation factor eIF-4E and eIF-4G.  J. Biol. Chem. 267:.

De Benedetti, A., Joshi-Barve, S., Rinker-Schaeffer, C.W., and Rhoads, R.E. (1991). Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the P220 component of eIF-4F.  Mol. Cell. Biol. 11:5435-5445.

De Benedetti, A. and Rhoads, R.E. (1991) A novel BK virus-based episomal vector for the expression of foreign genes in mammalian cells.  Nucl. Acid Res. 19:1925-1931.

De Benedetti, A. and Rhoads, R.E. (1990) Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.  Proc. Natl. Acad. Sci. USA 87:8212-8216.