Dr. John Clifford's Publications

Lah TT, Clifford JL, Helmer KM, Day NA, Moin K, Honn KV, Crissman JD, Sloane BF: Inhibitory properties of low molecular mass cysteine proteinase inhibitors from Human sarcoma. Biochim. Biophys. Acta 993:63-73, 1989.

Clifford JL, Petkovich M, Chambon P, and Lotan R: Modulation by retinoids of mRNA levels for nuclear retinoic acid receptors in murine melanoma cells. Molecular Endocrinology 4: 1546-1555, 1990.

Mendelsohn C, Larkin S, Mark M, LeMeur M, Clifford JL, Zelent A, and Chambon P: RAR b isoforms: distinct transcriptional control by retinoic acid and specific spatial Patterns of promoter activity during mouse embryonic development. Mechanisms of Development 45: 227-241, 1994.

Xu X, Clifford JL, Hong WK, Lotan R: Detection of nuclear retinoic acid receptor mRNA in histological tissue sections using non-radioactive in-situ hybridization histochemistry. Diagnostic Molecular Pathology, 3(2): 122-133, 1994.

Zhou C, Clifford JL, Xu X, Sacks P, Chambon P, Hong WK, and Lotan R: Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines. Cancer Research, 54: 5479-5487, 1994.

Metzger D, Clifford JL, Chiba H, and Chambon P: Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre-recombinase. Proc. Natl. Acad. Sci., USA, 92: 6991-6995, 1995.

Clifford JL, Chiba H, Sobieszczuk D, Metzger D, and Chambon P: RXR a-null F9 embryonal carcinoma cells are resistant to the differentiation, antiproliferative and apoptotic effects of retinoids. EMBO Journal, 15:4142-4155, 1996.

Chen J-Y, Clifford J, Zusi C, Starrett J, Tortolani D, Ostrowski J, Reczek PR, Chambon P, and Gronemeyer H. Two distinct actions of retinoid-receptor ligands. Nature, 382:819-822, 1996.

Chiba H, Clifford JL, Metzger D, and Chambon P. Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. Molec. and Cell. Biol., 17:3013-3020, 1997.

Chiba H, Clifford JL, Metzger D, and Chambon P. Specific and redundant functions of retinoid X receptor-retinoic acid receptor heterodimers in differentiation, proliferation and apoptosis of F9 embryonal carcinoma cells. J. Cell Biol., 139:735-747, 1997.

Clifford JL*, Menter DG, Wang M, Lotan R and Lippman SM. Retinoid receptor- dependent and -independent effects of N-(4-Hydroxyphenyl)retinamide in F9 embryonal carcinoma cells. Cancer Research, 59:14-18, 1999.

Li G, Walch E, Yang X, Lippman SM and Clifford JL*. Cloning and characterization of the human retinoid X receptor a gene: conservation of structure with the mouse homolog. Biochem. Biophys. Res. Commun., 269:54-57, 2000.

Clifford JL* , Menter DG, Yang X, Walch E, Zou CC, Clayman GL, Schaefer TS, El-Naggar AK, Lotan R and Lippman SM. Expression of protein mediators of type I interferon signaling in human squamous cell carcinoma of the skin. Cancer Epidem. Biomarkers and Prevention, 9:993-997, 2000.

Liu B, Lee H-Y, Weinzimer SA, Powell DR, Clifford JL, Kurie JM and Cohen P: Direct functional interactions between IGFBP-3 and RXR- a regulate transcriptional signalling and apoptosis. J. Biol. Chem., 275:, 2000.

Lee H-Y, Suh Y, Robinson MJ, Clifford JL, Hong WK, Woodgett JR, Cobb MH, Mangelsdorf DJ and Kurie JM. Stress pathway activation induces phosphorylation of retinoid X receptor. J. Biol. Chem., 275:, 2000.

Clifford JL*, Sabichi AL, Zou CC, Yang X, Steele VE, Kelloff GJ, Lotan R and Lippman SM. Effects of Novel Phenylretinamides on Cell Growth and Apoptosis in Bladder Cancer. Cancer Epidem. Biomarkers and Prevention, 10:391-395, 2001.

Shin DM, Glisson BS, Khuri FR, Clifford JL, Clayman G, Benner SE, Forastiere AA, Ginsberg L, Liu D, Lee JJ, Myers J, Goepfert H, Lotan R, Hong WK and Lippman SM. Phase II and biologic study of interferon alfa, retinoic acid, and cisplatin in advanced squamous skin cancer. J Clin. Oncology, 20:364-370, 2002.

Clifford JL* , Walch E, Yang X, Xu X, Alberts DS, Clayman GL, El-Naggar AK, Lotan R and Lippman SM. Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis. Clin. Cancer Res., 8:2067-2072, 2002.

Clifford JL* , Yang X, Walch E, Wang M and Lippman SM. Dominant Negative STAT2 Protein Blocks Interferon a Induced Growth Inhibition in Skin Squamous Cell Carcinoma Cells. Molecular Cancer Therapeutics, 2:453-459, 2003.

Sabichi AL, Fischer S, Zou CC, Yang X., Steele VE, Kelloff GJ, Lotan R, and Clifford JL.* Retinoid receptor-dependent and independent biological activities of novel Fenretinide analogs and metabolites. Clin. Cancer Res., 9:4606-4613, 2003.

Salas TR, Reddy SA, Clifford JL, Davis RJ, Kikuchi A, Lippman SM and Menter DG. Alleviating the suppression of glycogen synthase kinase-3 b by Akt leads to the phosphorylation of CREB and its transactivation in intact cell nuclei. J. Biol. Chem., 278:, 2003.

Tao Q, Cheng Y, Clifford J, and Lotan R. Characterization of the murine orphan G protein-coupled receptor gene mRai3 is regulated by retinoic acid. Genomics, 83:270-280, 2004.

Syson Chan K, Carbajal S, Kiguchi K, Clifford J , Sano S and DiGiovanni J. Activation of Stat3 during mouse skin tumor promotion and multistage skin carcinogenesis. Cancer Research, in press.