|Requirements for the Ph.D. Degree
E. Rhoads, Ph.D., Professor and Head 318-675-5161 (phone) [email protected]
Davis, Ph.D., Assistant Professor, Director of Graduate Studies,
318-675-5160 (phone) [email protected]
doctor of philosophy degree is conferred only for work of distinction
in which the student displays original scholarship. The Graduate
School of LSLTHSC and the faculty of the Department of Biochemistry
and Molecular Biology have instituted a program to provide students
the opportunity to distinguish themselves within a chosen field
of study. Students are trained to recognize significant biological
problems, to design experimental approaches to solving these problems,
and to communicate their results to the scientific community.
1. Course Requirements
core curriculum consists of a minimum of 18 credits in core courses
and 10 credits in elective courses for which a letter grade is assigned.
Students must maintain a minimum grade point average (GPA) of 3.0
in the core curriculum courses. Grades from courses outside the
core curriculum will not be included in the calculation of the GPA.
A student with a GPA of below 3.0 is immediately placed on probation
and the continuation of the student in the program is at the discretion
of the student's advisory committee. The advisory committee may
choose one of the following: 1) Removal of the student from the
graduate program, 2.) Require the completion of a M.S. degree (see
below), or 3.) Extend the probation to allow the student to attain
a GPA of 3.0. The probationary period may not extend beyond three
A. Core Courses
111-115 Biochemistry and Molecular and Cell Biology. These courses
provide instruction to the basics of proteins, enzymes, generation
of metabolic energy; metabolism and genetics; gene expression and
the cell cycle; and cell biology.
116-118 Methods in Biomedical Sciences. These courses provide
instruction to the principles and application of common methods
of biochemistry and molecular biology; biostatistics and recombinant
DNAI; and recombinant DNAII and cell biology.
223. Physical Biochemistry. Two hours of conference and lectures
involving discussions of physical and chemical techniques used in
biochemistry to study macromolecular architecture and interactions.
Director: Stephan Witt, Ph.D.
282. Protein Structure/Function. A series of lectures focused
on the use of state-of-the-art approaches to study protein structure,
protein folding and protein-ligand interactions. 1 credit. Taught
in the Spring semester of even-numbered years. Lecturer: Dr. Eric
288. Scientific Writing. I credit. A course designed to teach
fundamentals of writing a scientific paper, writing a grant proposal,
and identifying topics and approaches suitable for grant proposals.
Course offered Spring semester of every year; will be taught in
May 2001. Lecturer: Dr. Robert E. Rhoads.
B. Elective Courses
are required to choose at least four courses in the BCH 280 series
of Special Topics courses.
281. Molecular Mechanisms of Post?transcriptional Control. 1
credit. A literature-based course dealing with post-transcriptional
control of gene expression in eukaryotic cells and their viruses.
Topics will include mRNA splicing, mRNA stability, translational
control, and protein targeting. Offered in the Spring semester of
even-numbered years. Lecturers: Drs. Robert E. Rhoads and Ricky
283. Molecular Mechanisms of Transcriptional Control. 1 credit.
A literature-based course covering the role of promoter-specific
activators and repressors, the nature and role of the general transcriptional
machinery, and the role of nucleosomes and higher-order chromatin
structures in regulating transcription. Offered in the Spring semester
of odd-numbered years. Lecturers: Drs. David S. Gross and Shari
284. Mechanisms of Genetic Control: Signal Transduction Pathways.
1 credit. A literaturebased discussion course on the use of genetic
and developmental biology tools in diverse systems such as yeast,
Drosophila, Xenopus, and zebrafish to study signal transduction
pathways. The course will focus on several known signal transduction
pathways, and will include discussion of the experiments that were
performed to elucidate these pathways and of current problems in
the field. Discussion will emphasize critical evaluation of the
literature. Lecturer: Dr. Lucy Robinson. Offered in the Spring semester
of odd-numbered years;
285. Eukaryotic Developmental Biology. 1 credit. A literature-based
course that is focused on developmental regulatory mechanisms in
higher animals. Topics will include cell fate specification, differentiation
and pattern formation. Course taught Fall semester of even-numbered
years. Lecturer: Dr. Eric Aamodt.
286. Classical and Molecular Genetics. I credit. This course
will emphasize classical genetic methods as they apply to modern
molecular biology. The course content will rely on yeast as an experimental
organism, although the intent is to teach genetic principles as
they apply to eukaryotic organisms in general. Offered in the Fall
semester of odd-numbered years. Lecturers: Drs. Kelly Tatchell and
287. Applications of Spectroscopic Techniques to Biochemical
Problems. 1 credit. This course emphasizes the principles of well-establi
shed methods, such as fluorescence spectroscopy, and new methods,
such as surface plasmon resonance spectroscopy, and their applications
to biochemical problems. Offered in the Fall semester of odd-numbered
years. Lecturer: Dr. Stephan Witt.
C. Elective courses (Non-Departmental)
are required to choose at least six courses from the following:
201 Introduction to Human Cancer Research, Treatment and Prevention.
This will be a two credit introductory course team taught by basic
scientists and clinical scientists. Four topics will be covered
including: 1) an introduction and overview of cancer; 2) cancer
cell biology; 30 the diagnosis, treatment and prevention of cancer
and 4: the molecular pathogenesis and treatment of specific cancers.
The focus of this course will be to provide information concerning
what is currently understood about the biochemical mechanisms operating
during neoplasia and will include up to date information about oncogenes,
tumor suppressor genes, metastasis, angiogenesis, tumor immunology,
diagnostic approaches (conventional and molecular) and treatment
modalities. The course will consist of lectures that stress the
research approaches and finding that currently form the basis for
our understanding of how neoplastic cells arise and form cancers.
This course will form the basis for more advanced courses in the
cell and molecular biology of cancer.
212, IDSP 213, IDSP 214, IDSP 216, IDSP 217, IDSP 218, IDSP 219,
MICRO 276, MICRO 297, MICRO 291, MICRO 289
D. Additional Course Requirements
addition to the formal courses described above, students are required
to register for several courses for which a pass/fail decision,
rather than letter grade, is assigned upon completion of the course.
These courses include the following.
207. Introduction to Special Methods of Research. 1-6 credits.
This course provides the first-year students credit for their efforts
in laboratory rotation. Each new student is expected to participate
in three separate rotations, each of about 3 months duration.
298. Journal Club. 1 credit. Each student is expected to make
a one hour presentation from the current literature and participate
in all journal club meetings scheduled in the Fall and Spring semesters.
First and second year students should choose a faculty advisor who
is not their dissertation or rotation director to advise in choice
of topic and to critique the journal club both prior to and after
299. Research Seminar. 1 credit. This course offers credit for
participation in the departmental seminar program and student seminar
program. Each student is expected to present a formal research seminar
on their research project and participate in all departmental seminars
scheduled in the Fall and Spring semesters.
300. Thesis Research. 1-6 credits. This course offers credit
for research work applied to the Masters thesis.
400. Dissertation Research. 1-9 credits. This course provides
students credit for their research work applied to their Ph.D. dissertation.
D. Course Requirement Summary
B. Elective Courses (Departmental) Minimum requirement